Thomas,
Newt, and Frypan are the last of the free "Gladers" immune to the
Flare virus that has ravaged the world's population. They and The Right Arm
resistance conduct a rescue operation where they retrieve other Immunes from a
train, which is owned by WCKD, an organization responsible for capturing and
experimenting on immune children. They discover that Minho, their remaining
Glader friend whom WCKD had captured, was not on that train, which is headed to
"The Last City", WCKD's base of operations. Against the orders of
Vince, leader of The Right Arm, the three leave their camp to rescue Minho, who
is being tortured by WCKD in hopes of developing a cure for the virus. Heading
for the Last City, the group is attacked by Cranks, humans infected with the Flare.
However, they are saved by Jorge and Brenda, who join them.
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The group makes it to the wall of the Last City, which protects the city from Cranks. Outside the wall, people are rallying in protest to be let into the city. When WCKD opens fire at the protesters, the group is captured by a contingent of masked men and are taken to a hideout. One of the masked men is revealed to be Gally, who has survived Minho's attack at the end of The Maze Runner. Gally takes them to see Lawrence, a rebellion leader for those outside the walls, who helps them enter the Last City through a secret entrance. Gally leads Thomas and Newt through to the city and, spotting Teresa, Gally tells Thomas that she can get them into WCKD headquarters. Newt then confides to Thomas that he is infected. Promising to cure him, the three capture Teresa.
Thomas,
Newt, and Gally escort Teresa inside WCKD headquarters and toward the location
of the Immunes. Gally looks after the Immune children and stays to find a serum
that slows the Flare, while Thomas, Newt, and Teresa go to find Minho. They are
discovered and chased by Janson. Teresa lets them escape to find Minho before
rushing to do a blood test on Thomas' blood, which she obtained when removing
trackers from the Gladers.
Having
delivered the Immune children and the serum to Brenda, Gally returns to WCKD
headquarters to find Thomas. Brenda is forced to flee with the Immune children
to avoid capture. Thomas and Newt reunite with Minho in the medical wing.
Teresa discovers that Thomas' blood can cure the Flare. She shares her
discovery with WCKD's leader, Ava Paige, both agreeing that they must find
Thomas. Brenda and the Immune children escape WCKD with Frypan's help.
Meanwhile, Lawrence rallies his rebels outside the city before blowing a hole
in the city wall, sacrificing himself to allow his allies and the infected
people to storm the city. Gally finds Thomas, Minho, and Newt. Newt, sending
Minho and Gally ahead to get the serum from Brenda, gives Thomas a pendant
before passing out. Teresa transmits her voice throughout the city, telling
Thomas that his blood can save Newt if he will only return to WCKD. Newt,
nearly consumed by the Flare, regains consciousness and attacks Thomas, while
begging Thomas to kill him. When Thomas will not, Newt—left with no other
option—stabs himself.
Thomas makes
his way back to WCKD and confronts Ava. However, she is killed by Janson, who
is infected by the Flare. Janson knocks Thomas out and drags him to a lab where
Teresa is ready to extract his blood. However, he reveals that he is only truly
interested in curing himself, which results in Teresa turning on him. After a
fight, Janson is killed, allowing Thomas and Teresa to escape to the rooftop,
where Teresa gives Thomas a vial with the cure. Their allies suddenly appear in
an aircraft: Thomas makes it aboard, but Teresa dies when the headquarters
collapses in on itself.
The group
reunites with the rest of the Immunes and The Right Arm, escaping to a safe
haven, where the remaining population can live in safety. There, Thomas
discovers that the pendant Newt gave him had a note in it. Still traumatized by
his friends' deaths, he reads the note, in which Newt tells him to look after
everyone.
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